Keywords: Neurofluids, Brain, Bariatric Surgery, Glymphatic System, DTI-ALPS
Motivation: The effects of bariatric surgery on changes in the brain's glymphatic system in obese patients remain unclear.
Goal(s): To investigate the influence of bariatric surgery on the patients’ glymphatic system.
Approach: Data were collected from 41 obese patients who underwent bariatric surgery, including brain ALPS index, body fat area, hepatic fat content, and metabolic-related markers.
Results: The post-operative DTI-ALPS index showed a statistically significant increment compared to the pre-operative ones (p < 0.05). The DTI-ALPS index was positively correlated with visceral fat area, hepatic T2-star, C-peptide, BMI, and body weight, negatively correlated with LDL and cholesterol, all with statistical significance (p < 0.05).
Impact: This research suggests bariatric surgery can alter the brain's glymphatic system, highlighting its potential influence on cognitive health and opening avenues for further exploration of obesity-related neurological impacts.
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