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Abstract #5077

Bariatric Surgery Alters Brain Glymphatic Function in Obese Patients: A DTI-ALPS Study

Junhong Duan1, Yunjie Liao1, Peng Wu2, Jun Peng3, and Pengfei Rong1
1Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, China, 2Philips Healthcare, Shanghai, China, 3Philips Healthcare, Guangzhou, China

Synopsis

Keywords: Neurofluids, Brain, Bariatric Surgery, Glymphatic System, DTI-ALPS

Motivation: The effects of bariatric surgery on changes in the brain's glymphatic system in obese patients remain unclear.

Goal(s): To investigate the influence of bariatric surgery on the patients’ glymphatic system.

Approach: Data were collected from 41 obese patients who underwent bariatric surgery, including brain ALPS index, body fat area, hepatic fat content, and metabolic-related markers.

Results: The post-operative DTI-ALPS index showed a statistically significant increment compared to the pre-operative ones (p < 0.05). The DTI-ALPS index was positively correlated with visceral fat area, hepatic T2-star, C-peptide, BMI, and body weight, negatively correlated with LDL and cholesterol, all with statistical significance (p < 0.05).

Impact: This research suggests bariatric surgery can alter the brain's glymphatic system, highlighting its potential influence on cognitive health and opening avenues for further exploration of obesity-related neurological impacts.

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