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Abstract #5162

Reproducibility of T1 and T2 mapping on renal in-vivo data of 3T MRI scanners - a multi-center and multi-vendor study

Anika Strittmatter1,2, Anish Raj1,2, Siria Pasini3, Steffen Ringgaard 4, Leyre Garcia-Ruiz5, Giulia Villa3, Rebeca Echeverria-Chasco5, Michela Bozzetto3, Paolo Brambilla6, Matias Trillin7, Malene Aastrup4, Esben S.S. Hansen4, Ioana Adriana Urdea8, Larisa Micu8, Lucian-Mihai Itu8, José María Mora Gutierrez9, Nuria García Fernández9, Susan T Francis10, Christoffer Laustsen4, Maria A Fernandez-Seara5, Anna Caroli3, and Frank G Zöllner1,2
1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, 2Mannheim Institute for Intelligent Systems in Medicine, Heidelberg University, Mannheim, Germany, 3Bioengineering Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, 4The MR Research Centre, Aarhus University, Aarhus, Denmark, 5Department of Radiology, Clínica Universidad de Navarra, Pamplona, Spain, 6Radiology Unit, ASST Papa Giovanni XXIII, Bergamo, Italy, 7Renal Diseases Department, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy, 8Siemens Advanta, Brasov, Romania, 9Department of Nephrology, Clínica Universidad de Navarra, Pamplona, Spain, 10Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Kidney, Quantitative Imaging

Motivation: For quantitative MRI (qMRI), evaluating repeatability and reproducibility is vital for tackling the challenges of standardization.

Goal(s): Analyse repeatability and reproducibility of T1 mapping and T2 mapping on healthy volunteers.

Approach: Multi-site and multi-vendor study using two 3T scanners at two centers.

Results: The mean T1 and T2 differences between multiple acquisitions are not significant. T1 and T2 exhibit good repeatability and reproducibility across multiple acquisitions for differnt scanners and sites in healthy volunteers.

Impact: To address the standardization challenge of the MR protocol, assessing repeatability and reproducibility is essential. Our findings reveal that T1 and T2 MR biomarkers maintain high repeatability and reproducibility in healthy volunteers across multiple acquisitions

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Abstract

Keywords