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Abstract #5171

Association between glymphatic dysfunction and cognitive impairment in patients with hemodialysis

Yadong Cui1, Chong Zheng1, Boyan Xu2, and Jie Lu1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China, 2GE Healthcare, MR Research China, Beijing, China

Synopsis

Keywords: Kidney, Nervous system, Hemodialysis, Cognitive impairment; Glymphatic system, Choroid plexus volume, BOLD-CSF coupling

Motivation: While glymphatic system dysfunction is closely linked to dementia, its role in patients with hemodialysis (HD) remains unclear.

Goal(s): To evaluate the relationship between glymphatic function, cognitive performance, and clinical characteristics in HD patients.

Approach: Multimodal approaches were utilized, including CPV, BOLD-CSF coupling, and DTI-ALPS index, to evaluate to evaluate glymphatic function in HD patients and healthy controls, and to investigate their correlation with cognitive performance.

Results: HD patients exhibited impaired glymphatic function, indicated by increased CPV and decreased DTI-ALPS index. Importantly, the DTI-ALPS index was correlated with cognitive performance. Glymphatic dysfunction was an underlying mechanism account for cognitive impairment in HD patients.

Impact: Multimodal neuroimaging techniques could provide non-invasive assessment of glymphatic dysfunction in HD patients, providing new insights into the pathophysiology of cognitive impairment in HD patients.

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