Keywords: Task/Intervention Based fMRI, Blood vessels, fMRI (task based); Neuro; Vascular
Motivation: Cerebrovascular reactivity (CVR) is an important biomarker of brain’s vascular function.. BOLD-based CVR mapping techniques are susceptible to multiple BOLD confounding factors.
Goal(s): To develop a normalized CVR mapping approach using BOLD MRI with both hypercapnia and hyperoxia challenges and obtain CBF-CVR, which is independent of BOLD confounding factors while maintaining its superior sensitivity.
Approach: A proof-of-principle study was first performed in 7 healthy subjects, followed by a test-retest reproducibility study in 11 subjects.
Results: CBF-CVR obtained from the normalized CVR approach showed smaller inter-voxel coefficient of variance (CoV) and gray matter/white matter ratio than BOLD-CVR, and also reduced inter-subject variations.
Impact: The normalized CVR approach, using hypercapnia and hyperoxia challenges with BOLD acquisition to obtain CBF-CVR, can provide a more direct index of the microvascular function and would be practical and promising in clinical applications of cerebrovascular diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords