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Abstract #5195

Normalized cerebrovascular reactivity mapping using hypercapnia and hyperoxia challenges

Elham Karimigharighi1,2, Fariba Badrzadeh1, Hanzhang Lu3, and Peiying Liu1
1Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Baltimore, MD, United States, 2Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, United States, 3Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Task/Intervention Based fMRI, Blood vessels, fMRI (task based); Neuro; Vascular

Motivation: Cerebrovascular reactivity (CVR) is an important biomarker of brain’s vascular function.. BOLD-based CVR mapping techniques are susceptible to multiple BOLD confounding factors.

Goal(s): To develop a normalized CVR mapping approach using BOLD MRI with both hypercapnia and hyperoxia challenges and obtain CBF-CVR, which is independent of BOLD confounding factors while maintaining its superior sensitivity.

Approach: A proof-of-principle study was first performed in 7 healthy subjects, followed by a test-retest reproducibility study in 11 subjects.

Results: CBF-CVR obtained from the normalized CVR approach showed smaller inter-voxel coefficient of variance (CoV) and gray matter/white matter ratio than BOLD-CVR, and also reduced inter-subject variations.

Impact: The normalized CVR approach, using hypercapnia and hyperoxia challenges with BOLD acquisition to obtain CBF-CVR, can provide a more direct index of the microvascular function and would be practical and promising in clinical applications of cerebrovascular diseases.

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