Meeting Banner
Abstract #5199

Brain-wide functional mapping reveals deafening-induced cross-modal plasticity in mice

Won Beom Jung1,2, Hyun-Ji Shim3, Geun Ho Im2, Sangyeol Lee1, Gunsoo Kim4, and Seong-Gi Kim2
1Emotion, Cognition & Behavior Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea, Republic of, 2Center for Neuroscience Imaging Research (CNIR), Institute for Basic Science (IBS), Suwon, Korea, Republic of, 3Department of Mind Brain Institute, School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, United States, 4Sensory & Motor Systems Research Group, Korea Brain Research Institute (KBRI), Daegu, Korea, Republic of

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI (task based)

Motivation: Sensory deprivation in adults can induce substantial cortical reorganization.

Goal(s): This study investigated how auditory deprivation influences sensory networks across the brain in young adult mice

Approach: BOLD-fMRI on a 15.2T MRI was performed to determine brain-wide sensory reorganization in mice before and after deafening. Optical imaging and auditory cortex inactivation confirmed cross-modal plasticity associated with auditory input loss.

Results: Deafening rapidly enhances responses to somatosensory and visual stimuli within their respective sensory pathways, and these responses also emerged in the deprived auditory cortex. This reorganization extended into the thalamus and secondary cortices, indicating widespread cross-modal plasticity beyond primary sensory areas.

Impact: Our findings suggest that sensory deprivation can drive extensive functional reorganization, even in adulthood. Brain-wide functional imaging provides a powerful tool to reveal the scope and underlying mechanisms of cross-modal plasticity.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords