Abstract #5200

On the feasibility of myelin water imaging at low-field MRI using multi-echo GRASE

Gian Franco Piredda¹, Thomas Yu^1,2,3, Erick Jorge Canales-Rodríguez³, Lina Bacha^1,2,3, Tommaso Di Noto^1,2,3, Bénédicte Maréchal^1,2,3, Dominik Nickel⁴, Tobias Kober^1,2,3, and Tom Hilbert^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, ²Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴Siemens Healthineers AG, Erlangen, Germany

Synopsis

Keywords: Quantitative Imaging, Low-Field MRI, Neuro, White Matter, Multiple Sclerosis, Brain Development

Motivation: Low-field MRI may offer benefits for myelin water fraction (MWF) mapping due to the longer T₂ of water and more homogeneous B₀ and B₁⁺ fields compared to higher field strengths.

Goal(s): To investigate a multi-echo GRASE sequence for MWF mapping at 0.55T.

Approach: Four healthy volunteers were scanned using a multi-echo GRASE sequence with GRAPPA x2 and 2x2 acceleration. Images were reconstructed using both conventional GRAPPA and a deep learning-based method. Resulting MWF maps were compared visually and using a Bland-Altman analysis.

Results: Using GRAPPA 2x2 and deep-learning reconstruction, good quality MWF maps in agreement with GRAPPA x2 could be obtained in 6:41$$$\,$$$minutes.

Impact: By leveraging deep learning-based reconstructions, myelin water imaging is feasible at 0.55T with a multi-component decomposition of multi-echo T₂ data acquired in approximately 6 minutes at 2.5 mm isotropic resolution, encouraging further neuroimaging research at low field strengths.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.