Meeting Banner
Abstract #5201

Quantification of cortical and subcortical integrity within clinically feasible scan time using a 16-Tx/64-Rx RF array

Kerrin J Pine1, Pierre-Louis Bazin2, Evgeniya Kirilina1, and Nikolaus Weiskopf1,3,4
1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Full brain picture Analytics, Leiden, Netherlands, 3Felix Bloch Institute for Solid State Physics, Faculty of Physics and Earth System Sciences, Leipzig University, Leipzig, Germany, 4Wellcome Centre for Human Neuroimaging, Institute of Neurology, University College London, London, United Kingdom

Synopsis

Keywords: Quantitative Imaging, Neuro, brain, data acquisition, high-field MRI, new devices

Motivation: Ultra-high-resolution quantitative MRI offers sensitive markers for detecting cortical atrophy and neurodegeneration in brainstem nuclei; however, it typically requires lengthy acquisitions that are impractical in clinical settings.

Goal(s): We tested whether highly accelerated acquisition, using a high-performance head RF coil primarily designed for optimal cortical mapping, could achieve the accuracy needed for high-resolution quantitative brainstem imaging.

Approach: High-resolution multiparametric maps were acquired with acceleration factors up to x16, using both conventional and advanced coil arrays.

Results: With the advanced coil, high-quality qMRI data were obtained within clinically feasible times, enabling quantification of brainstem nuclei and characterization of cortical layers.

Impact: This is an important step toward the clinical translation of ultra-high-resolution qMRI. The high sensitivity achieved in cortical and brainstem imaging makes the tested RF array a valuable tool for detecting early neurodegeneration at prodromal stages of AD and PD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords