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Abstract #5230

High Resolution in vivo preclinical 1H-FID-MRSI using Compressed Sensing : when acceleration leads to precipitation

Brayan Alves1,2, Thanh Phong Lê1,2, Antoine Klauser3, Wolfgang Bogner4,5, Bernard Lanz1,2, Bernhard Strasser4, and Cristina Cudalbu1,2
1Centre d'Imagerie Biomedical - CIBM, Lausanne, Switzerland, 2Animal Imaging and Technology, EPFL, Lausanne, Switzerland, 3Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland, 4Department of Radiology, MR Center of Excellence, Medical University Vienna, Vienna, Austria, 5Christian Doppler Laboratory for MR Imaging Biomarkers (BIOMAK), Vienna, Austria

Synopsis

Keywords: Spectroscopy, Preclinical

Motivation: High-resolution preclinical magnetic resonance spectroscopic imaging applied in the rodent brain can offer a great deal of metabolite information, but at the cost of low temporal resolution.

Goal(s): Our goal was to explore 1H-MRSI with compressed sensing (CS) acceleration to reach higher resolution on the rat brain and investigate its benefits and shortcomings.

Approach: Free induction decay MRSI was acquired with a resolution of 31x31 and optimized CS was then used to reach 47x47 and 63x63 in an acceptable time.

Results: While concentration estimates and maps were preserved with each resolution, the lipid contaminations and increase in effective voxel size limited the method.

Impact: 1H-MRSI combined with CS could be useful for dynamic measurements over multiple repetitions. For higher resolution acquisition, the technique could be more suitable for 3D whole-brain acquisition or in combination with other acceleration techniques.

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