Meeting Banner
Abstract #5256

Radiomics Analysis of Cardiac Magnetic Resonance Images for Differentiating Fabry Disease from Hypertrophic Cardiomyopathy

Yen-Fang Huang1, Pao-Han Chiu1, Ming-Ting Wu2, Teng-Yi Huang3, Hsiao-Wen Chung4, and Hsu-Hsia Peng1
1Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, 2Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, 3National Taiwan University of Science and Technology, Taipei, Taiwan, 4Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan

Synopsis

Keywords: Myocardium, Radiomics, Fabry disease, Hypertrophic Cardiomyopathy

Motivation: A timely differential diagnosis of patients with Fabry disease (FD) from those with hypertrophic cardiomyopathy (HCM) is essential for treatment planning.

Goal(s): This study aimed to establish a radiomics classification model using CMR cine images to differentiate FD from HCM patients.

Approach: Radiomics features were extracted from cine images at end-diastole and end-systole. The random forest (RF) classification model was combined with feature selection methods of mutual information, ANOVA, and Chi2.

Results: The MI+RF model demonstrated good performance of AUC=0.92±0.02. Two selected features significantly differed between FD and HCM patients (p<0.05).

Impact: The RF classification combined with cine image features selected by MI could distinguish FD from HCM. The selected features included shape and texture categories, illustrating the potential of radiomics features in identifying subtle morphological and myocardial texture changes in FD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords