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Abstract #5257

MR-based evaluation of cardiac strain and ejection fraction in patients with dilated cardiomyopathy and hypertrophic cardiomyopathy

Jithin Sreekumar1, Monica Gunasingh1,2, Rolla Krishna Narayana3, Sashidhar Kaza4, Jaladhar Neelavalli1, and Bhairavi Pramod Reddy4
1Biomedical Engineering, Indian Institute of Technology, Hyderabad, Hyderabad, India, 2Philips India Limited, Chennai, India, 3Philips India Limited, Bangalore, India, 4Radiology, Asian Institute of Gastroenterology, Hyderabad, India

Synopsis

Keywords: Myocardium, Cardiomyopathy, Strain Analysis

Motivation: Echocardiography based cardiac strain evaluation is operative dependent. Cardiac MR is operator independent. Absence of Cardiac strain measures in Indian patient population.

Goal(s): To evaluate differences in cardiac strain between patients with Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), and controls, using CMR-FT and examine its correlation with ejection fraction (EF).

Approach: Retrospective cohort study analyzing clinical and imaging data from 224 subjects (98 HCM, 99 DCM, 27 controls) between 2022 and 2023.

Results: DCM patients showed a stronger correlation with EF compared to HCM patients and controls. Within the DCM and HCM groups, GCS had a slightly stronger correlation with EF than GLS.

Impact: This study highlights the potential of integrating strain data into clinical use as an early indicator for risk stratification, particularly in HCM patients, leading to effective interventions and improved outcomes.

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Keywords