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Abstract #5262

Effect of blood rheology and hematocrit on the estimation of hemodynamic parameters in hypertrophic cardiomyopathy

Julio Sotelo1, Hernan Mella2, Felipe Galarce3, Cristian Velasquez4, Sergio Uribe5, Tetsuro Sekine6, and Ernesto Castillo7
1Departamento de Informática, Universidad Técnica Federico Santa María, Santiago, Chile, 22School of Electrical Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, 3School of Civil Engineering, Pontificia Universidad Católica de Valparaíso, Valparaíso, Chile, 4Department of Emergency, Clínica los Carrera | Interclínica, Quilpué, Chile, 5Department of Medical Imaging and Radiation Science, Monash University, Melbourne, Australia, 6Department of Radiology, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan, 7Department of Mechanical Engineering, Universidad de Santiago de Chile, Santiago, Chile

Synopsis

Keywords: Flow, Cardiomyopathy, Hemodynamics Parameters

Motivation: The nonlinear behavior of blood flow depends mainly on the hematocrit percentage (Hct) and can be effectively described using models such as the power-law.

Goal(s): This study investigates the influence of blood rheology and Hct percentage on the estimation of wall shear stress, energy loss and oscillatory shear index, in patients with obstructive and non-obstructive hypertrophic cardiomyopathy.

Approach: Hemodynamic parameters were quantified using the 4D Flow Matlab Toolbox, an intra- and inter-observer analysis was performed. Non-parametric test were used for statistical analysis.

Results: Interobserver variability in hemodynamic parameters and significant differences between constant and variable viscosity, are presented especially in the diastolic phase.

Impact: This study shows the impact of incorporating nonlinear blood viscosity models in the estimation of hemodynamic parameters from 4D flow MR imaging in patients with hypertrophic cardiomyopathy. Variable viscosity model produces significant differences in diastolic phase.

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Keywords