Abstract #5266

Simultaneous 3-D adiabatic T1rho and quantitative susceptibility mapping for characterization of myocardial infarction in ex vivo mouse

Iida Räty¹, Olli Nykänen², Svetlana Laidinen¹, Anna-Kaisa Ruotsalainen¹, Mikko Nissi², and Elias Ylä-Herttuala³

¹A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Department of Technical Physics, University of Eastern Finland, Kuopio, Finland, ³Clinical Radiology Unit, Imaging Center, Kuopio University Hospital, Kuopio, Finland

Synopsis

Keywords: Myocardium, Quantitative Susceptibility mapping

Motivation: Adiabatic T₁_ρ relaxation time and Quantitative Susceptibility mapping acquired using single imaging sequence are used to determine injured areas in the myocardium after myocardial infarction (MI)

Goal(s): The aim was to determine the MI area by acquiring T₁_ρ relaxation time and quantitative susceptibility maps with one scan.

Approach: Mice hearts were imaged ex vivo 14 days after MI by using a T₁_ρ weighted 3-D gradient‐recalled multi‐echo MRI.

Results: Both T₁_ρ relaxation times and quantitative susceptibility values were altered in the infarcted area compared to the remote area.

Impact: This study presents a simultaneous T₁_ρ and QSM measurement for ex vivo assessment of myocardium after factitious myocardial infarction in mice. The method allowed determination of myocardial infarction based on co-localized 3-D T₁_ρ relaxation time and quantitative susceptibility maps.

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