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Abstract #5267

Single-Sequence One-Stop Ferumoxytol-Enhanced Vascular Lumen and Wall Imaging (SSO-FE-VLWI) for Comprehensive Cardiovascular Assessment

Guangxiang Si1, Guangyan Wu2, Peigen Wang2, Jiaqi Wei2, Chuanshuai Tian2, Pu-Yeh Wu3, Peng Han2, Dan Mu2, Min Zhou2, and Ning Gu1,2
1Southeast University, Nanjing, China, 2Nanjing Drum Tower Hospital, Nanjing, China, 3GE Healthcare, Beijing, China

Synopsis

Keywords: Vascular/Vessel Wall, Cardiovascular, Ferumoxytol, Vessel Wall, Vascular Lumen, Contrast Agents

Motivation: Current ferumoxytol-enhanced MRA protocols focus on lumen imaging, requiring additional sequences for vessel wall assessment, which increases scan times and motion artifacts.

Goal(s): To assess the feasibility and effectiveness of Single-Sequence One-Stop Ferumoxytol-Enhanced Vascular Lumen and Wall Imaging (SSO-FE-VLWI) for simultaneous visualization of the vascular lumen and vessel wall in a single rapid acquisition.

Approach: Ten patients with atherosclerosis underwent SSO-FE-VLWI. T2-DIR was used for vessel wall validation, with comparison to non-enhanced in-phase images.

Results: SSO-FE-VLWI provided clear delineation of both the vascular lumen and vessel wall, showing significantly greater vessel wall visualization compared to non-enhanced imaging, with spatial overlap validating accuracy.

Impact: SSO-FE-VLWI provides a time-efficient approach for comprehensive vascular evaluation, reducing the need for additional sequences and improving clinical workflow.

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Keywords