Abstract #5274

Single breath-hold EPI-based 3D Late Gadolinium Enhancement Imaging

Oscar Goldman^1,2, Karl-Philipp Kunze^1,2,3, John Whitaker², and Radhouene Neji^1,2

¹Imaging Physics and Engineering research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ²Cardiovascular Imaging research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom

Synopsis

Keywords: Myocardium, Parallel Imaging, Late Gadolinium Enhancement

Motivation: 3D Late Gadolinium Enhanced MRI can suffer from long scan times which can be difficult for some patients to tolerate.

Goal(s): Design a 3D single breath-hold LGE-MRI sequence able to acquire whole-heart LGE images.

Approach: Implement an inversion recovery–prepared segmented 3D EPI sequence with a blipped-CAIPI undersampling pattern and an iterative SENSE reconstruction.

Results: Two patients were scanned with the proposed sequence, demonstrating that 3D whole-heart LGE images can be reconstructed from data acquired during a single, 19 heartbeat breath-hold, with a total undersampling factor of 4.

Impact: Using EPI readouts for LGE-MRI allows 3D images to be acquired in one breath-hold, with less undersampling than previously proposed methods. Further developments to the reconstruction could improve the resolution, to match what can be realised in longer, free-breathing acquisitions.

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