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Abstract #5280

Fully Quantitative CMR First-Pass Perfusion Reveals Myocardial Perfusion Impairment in Kawasaki Disease: Association with LV Remodeling

Ling-yi Wen1, Zhongqin Zhou1, Shengkun Peng1,2, Shiganmo Azhe1, Lei Hu1, Meining Chen3, and Yingkun Guo1
1Radiology, West China Second University Hospital, 610041, China, 2Department of Radiology, Sichuan provincial people's hospital, Chengdu, China, 3MR Research Collaboration, Siemens Healthineers Ltd., Chengdu, China

Synopsis

Keywords: Cardiovascular, Perfusion, Kawasaki Disease

Motivation: Kawasaki disease (KD) is associated with various myocardial injuries, including myocardial perfusion impairment, which is poorly defined.

Goal(s): To assess the distribution and determinants of myocardial perfusion impairment in KD using fully quantitative CMR first-pass perfusion and explore their relationships with left ventricular (LV) remodeling.

Approach: In a prospective study, 87 children with KD underwent fully quantitative CMR first-pass perfusion. Myocardial blood flow (MBF) was measured and correlated with LV remodeling indicators.

Results: Perfusion impairment was prominent in the acute KD phase and mid-giant CAA cases, particularly in the left coronary territory, correlating with decreased LV systolic function and increased LV remodeling.

Impact: The study provides further evidence about the usefulness of fully quantitative CMR first-pass perfusion in children. Moreover, the results can contribute to studies that aim to improve the diagnosis and management of myocardial perfusion impairment in children with KD.

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