Abstract #5283

Combining Arterial Spin Labeling and Cardiovascular Indices in Children with Pulmonary Embolism

Pezad Doctor¹, Lauren Thai², Steven Philip², Buford Scott², Yuland Tyner², Josh Greer³, Munes Fares², Mansi Gaitonde², Lasya Gaur², Gerald Greil², Qing Zou², Ayesha Zia⁴, and Tarique Hussain²

¹Division of Pediatric Cardiology, Children's Health, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Pediatric Cardiology, Children's Health, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Phillips, Cincinnati, OH, United States, ⁴Pediatric Hematology, Children's Health, University of Texas Southwestern Medical Center, Dallas, TX, United States

Synopsis

Keywords: Cardiovascular, Pediatric, Arterial spin labeling, Pulmonary perfusion, cardiovascular indices, supine bike ergometry

Motivation: Arterial spin labeling (ASL) is a non-contrast, free-breathing sequence that is recently used for assessing lung perfusion

Goal(s): We assessed utility of ASL for detecting pulmonary perfusion defects and correlate perfusion defects with cardiac indices in children ≤ 18 years diagnosed with pulmonary embolism

Approach: Sagittal ASL using MS-FAIR was used to detect pulmonary perfusion. CMR indices at rest and supine bike ergometry were analyzed and compared with perfusion defect.

Results: Of the 27 studies, ASL detected perfusion defects in all 19 studies performed within 4 weeks of PE diagnosis. An inverse correlation between perfusion defect and LV end-diastolic volume index was found.

Impact: ASL is a non-contrast, free breathing sequence that detects pulmonary perfusion defects in children with pulmonary embolism. An inverse correlation between perfusion defect and LV end-diastolic volume index was found, providing insights into cardiopulmonary interactions and potential therapeutics.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.