Meeting Banner
Abstract #5301

Water T1 Values Derived from MR Spectroscopy: A Novel Biomarker for Liver Fibrosis Assessment

Makoto Suzuki1, Tatsuya Hayashi2, Nashiki Kazutaka1, Hitoshi Tanigawa1, Hidemichi Kawata1, Shuji Nagata3, Tatsuyuki Tounan3, Takumi Kawaguchi3, and Shuichi Tanoue3
1Kurume university hospital, Kurume, Japan, 2Department of Radiological Technology Faculty of Medical Technology, Teikyo University, Tokyo, Japan, 3Kurume university, Kurume, Japan

Synopsis

Keywords:

Motivation: While MRI offers non-invasive alternatives to biopsy, conventional MOLLI T1 mapping is affected by hepatic fat content, limiting accurate fibrosis assessment in clinical practice.

Goal(s): To evaluate water T1 values from MR spectroscopy as a fat-independent biomarker for comprehensive liver fibrosis assessment using standard MR systems.

Approach: We compared water T1 values from MR spectroscopy with MOLLI T1 mapping in 102 patients at 3T, before and after Gd-EOB-DTPA administration.

Results: Pre-water T1 values showed stage-dependent differences (F0: 971.62±166.70ms vs F4: 1314.62±302.39ms; P<0.01, r=0.63). For diagnosing advanced fibrosis (≥ F3), pre-water T1 values achieved robust diagnostic performance (AUC: 0.81).

Impact: Pre-water T1 values enable non-invasive liver fibrosis assessment using conventional MR systems without contrast agents or specialized elastography hardware. This accessible approach could revolutionize clinical practice by providing accurate fibrosis evaluation with minimal technical requirements.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords