Abstract #5329

Assessment of IVIM-Derived Microcapillary Perfusion in Osteoporotic Vertebral Fractures

Hiroyuki Takashima¹, Rui Imamura², Yasuhisa Abe³, Tomonori Morita⁴, Ryunosuke Fukushi⁴, Yoshihiro Akatsuka², and Tsuneo Takebayashi³

¹Division of Biomedical Science and Engineering, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan, ²Division of Radiology and Nuclear Medicine, Sapporo Medical University Hospital, Sapporo, Japan, ³Sapporo Maruyama Orthopedic Hospital, Sapporo, Japan, ⁴Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan

Synopsis

Keywords:

Motivation: Osteoporotic vertebral fractures (OVF) frequently lead to delayed healing and reduced mobility in the elderly, increasing long-term care needs. A non-invasive method to assess fracture perfusion characteristics could aid in early intervention.

Goal(s): This study aims to evaluate IVIM MRI’s ability to differentiate perfusion in fractured versus non-fractured vertebrae and establish baseline data for OVF prognostic assessments.

Approach: In 52 patients with acute OVF, IVIM parameters (ADC, D, D*, f) were measured and analyzed for inter-rater reliability and statistical differences.

Results: IVIM parameters showed strong reliability and significant differences between fractured and non-fractured vertebrae, supporting IVIM’s potential for OVF assessment and early intervention.

Impact: This study establishes IVIM as a reliable, non-invasive tool for assessing perfusion in osteoporotic vertebral fractures, providing baseline data for prognostic use. Findings may support early interventions, improving outcomes and potentially reducing long-term care needs in elderly populations.

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