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Abstract #5346

Estimation of Hepatic Iron Concentration (HIC) on Patients with High Iron Burden

Mark Smith1, Larry Martin2, Brett Bryan2, Judd Storrs1, and Mitchell Rees1
1Nationwide Children's Hospital, Columbus, OH, United States, 2Ohio State University Medical Center, Columbus, OH, United States

Synopsis

Motivation: Patients with elevated hepatic iron concentration (HIC) require ongoing monitoring and treatment. Multi-echo GRE is used to generate R2*/T2* maps which allow quantification of HIC, but the maps are prone to failure in patients with high HIC.

Goal(s): When multi-echo GRE R2*/T2* maps fail, manual calculation of hepatic T2* may be necessary to accurately quantify hepatic T2*.

Approach: Pixel intensity measurements from short and long TE scans were manually recorded in hepatic regions of interest (ROI's). T2* was then calculated using the natural log (ln) equation T2* = -t / (Mxy/M0)ln.

Results: HIC was accurately quantified by manually calculating T2*.

Impact: R2*/T2* maps generated from multi-echo GRE scans are used to quantify hepatic iron concentration (HIC), but these maps are prone to failure in patients with high HIC. Manual calculation of hepatic T2* may be necessary for these patients.

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