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Abstract #5373

Development and Validation of a PVP-Based Phantom for ADC Measurement in Simulated Malignant Disease

Eisuke Sato1, Miku Yamasaki2, Toshiya Akatsu3, Tomonori Isobe4, and Tetsuya Yamamoto5
1Juntendo University, Tokyo, Japan, 2Juntendo University Urayasu Hospital, Urayasu, Japan, 3Juntendo University Hospital, Tokyo, Japan, 4University of Tsukuba, Tsukuba, Japan, 5Yokohama City University, Yokohama, Japan

Synopsis

Motivation: ADC measurement using diffusion-weighted imaging helps distinguish malignant from benign lesions. Accurate ADC quantification is critical for diagnosis, but existing phantoms are limited.

Goal(s): To develop a stable, reproducible PVP-based phantom that simulates malignant ADC values, enabling accurate measurements.

Approach: PVP phantoms with varying concentrations were prepared and scanned with a 1.5-tesla MR system. ADC values were derived and compared to those reported for malignant diseases.

Results: ADC values in the phantoms closely matched literature values for various cancers, and remained stable over 16 weeks with less than 4.0% variation.

Impact: This phantom could standardize ADC measurement, aiding more accurate diagnosis and opening pathways to refine ADC-based diagnostic tools and protocols.

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