Motivation: ADC measurement using diffusion-weighted imaging helps distinguish malignant from benign lesions. Accurate ADC quantification is critical for diagnosis, but existing phantoms are limited.
Goal(s): To develop a stable, reproducible PVP-based phantom that simulates malignant ADC values, enabling accurate measurements.
Approach: PVP phantoms with varying concentrations were prepared and scanned with a 1.5-tesla MR system. ADC values were derived and compared to those reported for malignant diseases.
Results: ADC values in the phantoms closely matched literature values for various cancers, and remained stable over 16 weeks with less than 4.0% variation.
Impact: This phantom could standardize ADC measurement, aiding more accurate diagnosis and opening pathways to refine ADC-based diagnostic tools and protocols.
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