Keywords: Unmet Needs
Motivation: Glioblastoma's aggressive recurrence and conventional MRI limitations in pseudoprogression discrimination drove our assessment of non-Gaussian diffusion biomarkers for personalized surgical/adjuvant therapy planning.
Goal(s): A reliable method for distinguishing between recurrence and pseudoprogression in Glioblastoma patients (9009).
Approach: This prospective study analyzed 55 biopsy-proven glioblastoma cases. Automated segmentation of preoperative and recurrence-phase MRI delineated tumor/edema regions. Non-Gaussian diffusion-derived histogram metrics compared recurrence-associated versus non-recurrent peritumoral edema subregions
Results: Recurrence regions exhibited statistically significant differences (p<0.05) in histogram parameters compared to non-recurrence regions, highlighting the clinical utility of non-Gaussian diffusion models in identifying occult tumor infiltration
Impact: Non-Gaussian diffusion MRI detects occult tumor infiltration in peritumoral edema (invisible on conventional MRI), enhancing recurrence/pseudoprogression prediction to optimize GBM surgical and adjuvant therapy.
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